Glycol monoethyl ether → HCID 57699670, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of potassium t.butoxide (9.3 g, 82.8 mmol) in 1-ethoxy-2-ethanol (70 ml) was added 2-chloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine (7 g, 27.6 mmol). The mixture was heated to 80-90° C. for 2 h. Then most of the solvent was removed by evaporation under reduced pressure. The residue was partitioned between water and dichloromethane. The dichloromethane layer was separated, concentrated to give a light brown solid, which was washed with petroleum ether, dried in vacuo (7.8 g, 92%).

Provenance & Evidence