N-bromobutanimide → HCID 57699765, compound

Participants

Reaction Steps

To a stirred solution of 2-{[2-(ethyloxy)ethyl]oxy}-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine (7.8 g, 25.4 mmol) in dichloromethane (100 ml) and NBS (5 g, 27.9 mmol) added with stirring. After 2 h, the solvent was removed. The product was purified through a silica column using petroleum ether: ethyl acetate 2:1 as eluent, which was a pale yellow solid (7.8 g, 79.6%).

Provenance & Evidence