Methanol → HCID 57699743, compound

Participants

Reaction Steps

Sodium (1.25 g, 54.4 mmol) was dissolved in methanol (40 ml). After 10 min, 8-bromo-2-{[2-(ethyloxy)ethyl]oxy}-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine (7 g, 18 mmol) was added with stirring. The mixture was heated to reflux for 2 h. The solvent was removed. The residue on a silica column using DCM: MeOH 100:1 as eluent to give the product as a yellow solid (4.78 g, 78.4%).

Provenance & Evidence