HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-bromobutanimide → 8-Bromo-2-{[1-methyl-2-(methoxy)ethyl]oxy}-9-(tetrahydro-2H-Pyran-2-yl)-9H-purin-6-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 2-{[1-Methyl-2-(methoxy)ethyl]oxy}-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine | HCID 57699634 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 8-Bromo-2-{[1-methyl-2-(methoxy)ethyl]oxy}-9-(tetrahydro-2H-Pyran-2-yl)-9H-purin-6-amine | HCID 57699655 | 81.1% |
Reaction Steps
To a stirred solution of 2-{[1-methyl-2-(methoxy)ethyl]oxy}-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine (7.2 g, 23.4 mmol) in dichloromethane (100 ml) was added NBS (4.6 g, 25.8 mmol). After 4 h, the solvent was removed. The product was purified on a silica column using petroleum ether: ethyl acetate 2:1 as eluent. This gave the product (7.3 g, 81.1%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07977344B2 |
| Source dataset | uspto-grants-2011_07 |
| ORD ID | ord-050983c4f02c4d579363bfdb0b5e0434 |
| Source note | uspto-grants-2011_07 |