反应详情

A solution of 2-chloro-9-(tetrahydro-2H-pyran-4-ylmethyl)-9H-purin-6-amine (150 mg) in cyclohexylamine (363 ul) was heated in the microwave at 170° C. for five minutes. The crude reaction mixture was subjected to C18 reverse phase chromatography using water (containing 0.1% formic acid)-acetonitrile (containing 0.05% formic acid) as eluant (20-60%) to afford a white solid (98 mg).

1. customThe crude reaction mixture