反应详情

温度

85 °C

Potassium tert.-butoxide (46.5 g, 475 mmol) was added to 2-methoxyethanol (200 mL) in 20 min at room temperature, then 2-chloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine (30 g) was added and the resulted mixture was heated at 80-90° C. for about 3 h. Evaporation of most of the solvent, to the residue was added 100 ml of water, stirred for 1 h at 0° C., filtered and dried. This gave product (30 g, 87%) that was almost identical to that from Intermediate 119, method A.

1. customEvaporation of most of the solvent
2. additionto the residue was added 100 ml of water
3. filtrationfiltered
4. customdried