反应详情

A stirring suspension of 8-bromo-2-[(2-cyclopropylethyl)oxy]-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine (7.96 g) in methanol (80 ml) was treated with 25 wt % sodium methoxide in methanol (14.29 ml) and refluxed under nitrogen for 3.5 h. After allowing to cool over 16 h the solvent was evaporated and the residue treated with saturated ammonium chloride and extracted twice with ethyl acetate. The combined extracts were washed with brine, dried by passing through a hydrophobic frit and evaporated to give the title compound as a brown solid, yield 6.49 gm.

1. temperaturerefluxed under nitrogen for 3.5 h
2. temperatureto cool over 16 h the solvent
3. customwas evaporated
4. additionthe residue treated with saturated ammonium chloride
5. extractionextracted twice with ethyl acetate
6. washThe combined extracts were washed with brine
7. customdried
8. customevaporated