2-(3-Bromopropyl)oxolane → 2-(Butyloxy)-8-(methyloxy)-9-[3-(tetrahydro-2-furanyl)propyl]-9H-purin-6-amine

HRID 1011089Notes

Reaction equation

HRID 1011089 reaction equation
FC(F)(F)C(O)=O.[CH2:8]([O:12][C:13]1[NH:14][C:15]([NH2:24])=[C:16]2[C:20]([N:21]=1)=[N:19][C:18]([O:22][CH3:23])=[N:17]2)[CH2:9][CH2:10][CH3:11].Br[CH2:26][CH2:27][CH2:28][CH:29]1[CH2:33][CH2:32][CH2:31][O:30]1>>[CH2:8]([O:12][C:13]1[N:21]=[C:20]2[C:16]([N:17]=[C:18]([O:22][CH3:23])[N:19]2[CH2:26][CH2:27][CH2:28][CH:29]2[CH2:33][CH2:32][CH2:31][O:30]2)=[C:15]([NH2:24])[N:14]=1)[CH2:9][CH2:10][CH3:11]

Participants

3

Reactant 2

HCID 157837122-(3-Bromopropyl)oxolaneHCID 178450357HCID 178450357, compound

Product 1

HCID 576996952-(Butyloxy)-8-(methyloxy)-9-[3-(tetrahydro-2-furanyl)propyl]-9H-purin-6-amine

Procedure

Prepared similarly to Intermediate 216 from 2-(butyloxy)-8-(methyloxy)-1H-purin-6-amine trifluoroacetate and 2-(3-bromopropyl)tetrahydrofuran.

Sources & evidence

ORD record
ord-4d8c2c24d49042b0ba4d6ea1e880eebc
Source dataset
uspto-grants-2011_07
Patent number
US07977344B2

Reaction notes

Loading…