4-(3-Bromopropyl)oxane → 2-[(2-Cyclopropylethyl)oxy]-8-(methyloxy)-9-[3-(tetrahydro-2H-pyran-4-yl)propyl]-9H-purin-6-amine

HRID 1011118Notes

Reaction equation

HRID 1011118 reaction equation
FC(F)(F)C(O)=O.[CH:8]1([CH2:11][CH2:12][O:13][C:14]2[NH:15][C:16]([NH2:25])=[C:17]3[C:21]([N:22]=2)=[N:20][C:19]([O:23][CH3:24])=[N:18]3)[CH2:10][CH2:9]1.Br[CH2:27][CH2:28][CH2:29][CH:30]1[CH2:35][CH2:34][O:33][CH2:32][CH2:31]1>>[CH:8]1([CH2:11][CH2:12][O:13][C:14]2[N:22]=[C:21]3[C:17]([N:18]=[C:19]([O:23][CH3:24])[N:20]3[CH2:27][CH2:28][CH2:29][CH:30]3[CH2:35][CH2:34][O:33][CH2:32][CH2:31]3)=[C:16]([NH2:25])[N:15]=2)[CH2:10][CH2:9]1

Participants

3

Reactant 2

HCID 576997044-(3-Bromopropyl)oxaneHCID 178494009HCID 178494009, compound

Product 1

HCID 576997552-[(2-Cyclopropylethyl)oxy]-8-(methyloxy)-9-[3-(tetrahydro-2H-pyran-4-yl)propyl]-9H-purin-6-amine

Procedure

Prepared similarly to Intermediate 220 from 2-[(2-cyclopropylethyl)oxy]-8-(methyloxy)-1H-purin-6-amine trifluoroacetate and 4-(3-bromopropyl)tetrahydro-2H-pyran.

Sources & evidence

ORD record
ord-4087750cad2a46f29ccd7685a5ab684e
Source dataset
uspto-grants-2011_07
Patent number
US07977344B2

Reaction notes

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