2-(3-bromopropyl)tetrahydro-2H-pyran → HCID 57699614, compound

HRID 1011127Notes

Reaction equation

HRID 1011127 reaction equation
FC(F)(F)C(O)=O.[CH3:8][C@H:9]([O:13][C:14]1[NH:15][C:16]([NH2:25])=[C:17]2[C:21]([N:22]=1)=[N:20][C:19]([O:23][CH3:24])=[N:18]2)[CH2:10][CH2:11][CH3:12].Br[CH2:27][CH2:28][CH2:29][CH:30]1[CH2:35][CH2:34][CH2:33][CH2:32][O:31]1>>[CH3:8][C@H:9]([O:13][C:14]1[N:22]=[C:21]2[C:17]([N:18]=[C:19]([O:23][CH3:24])[N:20]2[CH2:27][CH2:28][CH2:29][CH:30]2[CH2:35][CH2:34][CH2:33][CH2:32][O:31]2)=[C:16]([NH2:25])[N:15]=1)[CH2:10][CH2:11][CH3:12]

Participants

3

Reactant 2

HCID 107746932-(3-bromopropyl)tetrahydro-2H-pyranHCID 178448285HCID 178448285, compound

Product 1

HCID 57699614HCID 57699614, compound

Procedure

Prepared similarly to Intermediate 220 from 2-{[(1S)-1-methylbutyl]oxy}-8-(methyloxy)-1H-purin-6-amine trifluoroacetate and 2-(3-bromopropyl)tetrahydro-2H-pyran.

Sources & evidence

ORD record
ord-242b7435818d4f41927d64a0c36d0d94
Source dataset
uspto-grants-2011_07
Patent number
US07977344B2

Reaction notes

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