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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1011136Generated: October 27, 2026

3-(4-Bromobutyl)oxolane → 2-{[(1R)-1-Methylbutyl]oxy}-8-(methyloxy)-9-[4-(tetrahydro-3-furanyl)butyl]-9H-purin-6-amine

https://huagongshe.com/reaction/1011136

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(4-Bromobutyl)oxolaneHCID 57699612—
ReactantHCID 178448284HCID 178448284—
Product2-{[(1R)-1-Methylbutyl]oxy}-8-(methyloxy)-9-[4-(tetrahydro-3-furanyl)butyl]-9H-purin-6-amineHCID 57699590—

Reaction Steps

Prepared similarly to Intermediate 216 from 2-{[(1R)-1-methylbutyl]oxy}-8-(methyloxy)-1H-purin-6-amine trifluoroacetate and 3-(4-bromobutyl)tetrahydrofuran.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07977344B2
Source datasetuspto-grants-2011_07
ORD IDord-2b2c695ebce74de688927ee5f45cf728
Source noteuspto-grants-2011_07