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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1011140Generated: November 3, 2026

3-(2-Bromoethyl)tetrahydro-2H-pyran → 2-{[(1R)-1-Methylbutyl]oxy}-8-(methyloxy)-9-[2-(tetrahydro-2H-Pyran-3-yl)ethyl]-9H-purin-6-amine

https://huagongshe.com/reaction/1011140

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(2-Bromoethyl)tetrahydro-2H-pyranHCID 54494306—
ReactantHCID 178448284HCID 178448284—
Product2-{[(1R)-1-Methylbutyl]oxy}-8-(methyloxy)-9-[2-(tetrahydro-2H-Pyran-3-yl)ethyl]-9H-purin-6-amineHCID 57699823—

Reaction Steps

Prepared similarly to Intermediate 213 from 2-{[(1R)-1-methylbutyl]oxy}-8-(methyloxy)-1H-purin-6-amine trifluoroacetate and 3-(2-bromoethyl)tetrahydro-2H-pyran.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07977344B2
Source datasetuspto-grants-2011_07
ORD IDord-7bf3aa38e8914411b642d8b4e1c8ac97
Source noteuspto-grants-2011_07