HCID 57699661, compound → HCID 57699760, compound

HRID 1011147Notes

Reaction equation

HRID 1011147 reaction equation
FC(F)(F)C(O)=O.[CH3:8][C@@H:9]([O:13][C:14]1[NH:15][C:16]([NH2:25])=[C:17]2[C:21]([N:22]=1)=[N:20][C:19]([O:23][CH3:24])=[N:18]2)[CH2:10][CH2:11][CH3:12].Br[CH2:27][CH2:28][CH2:29][CH2:30][CH:31]1[CH2:36][CH2:35][O:34][C:33]([CH3:38])([CH3:37])[CH2:32]1>>[CH3:37][C:33]1([CH3:38])[CH2:32][CH:31]([CH2:30][CH2:29][CH2:28][CH2:27][N:20]2[C:19]([O:23][CH3:24])=[N:18][C:17]3[C:21]2=[N:22][C:14]([O:13][C@H:9]([CH3:8])[CH2:10][CH2:11][CH3:12])=[N:15][C:16]=3[NH2:25])[CH2:36][CH2:35][O:34]1

Participants

3

Reactant 2

HCID 57699661HCID 57699661, compoundHCID 178448284HCID 178448284, compound

Product 1

HCID 57699760HCID 57699760, compound

Procedure

Prepared similarly to Intermediate 223 from 2-{[(R) —-methylbutyl]oxy}-8-(methyloxy)-1H-purin-6-amine trifluoroacetate and 4-(4-bromobutyl)-2,2-dimethyltetrahydro-2H-pyran but conducting the alkylation over 1 hour at 60° C.

Workup

  1. customover 1 hour
  2. customat 60° C.

Sources & evidence

ORD record
ord-d84a9f7160af469982ce6246b646b37f
Source dataset
uspto-grants-2011_07
Patent number
US07977344B2

Reaction notes

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