Hydrochloric Acid → HCID 25024973, compound

Participants

Reaction Steps

2-Butoxy-8-methoxy-9-(tetrahydro-2H-pyran-4-ylmethyl)-9H-purin-6-amine (0.22 g) was dissolved in methanol (10 mL) and treated with 4N hydrogen chloride in 1,4-dioxane (1 mL). The reaction was stirred at room temperature 16 hours and stripped to give a solid that was suspended in water (2 mL) before sufficient methanol was added until a solution was obtained. 2N Sodium hydroxide solution was added to bring to pH 7, and the solution concentrated until a suspension formed. The white solid was filtered and washed with water (2 mL, twice to complete transfer and wash). This was dried under suction and then under vacuum at 50° C. to give the title compound as a white solid (0.189 g).

Provenance & Evidence