Hydrochloric Acid → 6-Amino-2-[(2,2-dimethylpentyl)oxy]-9-(tetrahydro-2H-pyran-4-ylmethyl)-7,9-dihydro-8H-purin-8-one

Participants

Reaction Steps

To a solution of 2-[(2,2-dimethylpentyl)oxy]-8-methoxy-9-(tetrahydro-2H-pyran-4-ylmethyl)-9H-purin-6-amine (116 mg) in dry MeOH (14.5 mL) was added 4N HCl in 1,4-dioxane (2.48 mL). The mixture was stirred at room temperature for 3 h. The reaction was neutralised to pH 7 with 2M sodium hydroxide solution and was concentrated in vacuo to give and off-white solid. The solid was triturated with water (30 mL) and was filtered under reduced pressure to give the title compound as an off-white solid (76 mg).

Provenance & Evidence