Hydrochloric Acid → 6-Amino-2-[(3-methylbutyl)oxy]-9-(tetrahydro-2H-Pyran-4-ylmethyl)-7,9-dihydro-8H-purin-8-one

Participants

Reaction Steps

To a solution of 2-[(3-methylbutyl)oxy]-8-methoxy-9-(tetrahydro-2H-pyran-4-ylmethyl)-9H-purin-6-amine (52 mg) in dry MeOH (5.7 mL) was added 4N HCl in 1,4-dioxane (0.971 mL) and the reaction mixture was stirred at room temperature for 3 h. The reaction was neutralised to pH7 with 2M sodium hydroxide solution and concentrated in vacuo to give a white solid. The solid was washed with water (20 mL) and was filtered under reduced pressure to give the title compound as an off-white solid (31 mg).

Provenance & Evidence