Hydrochloric Acid → 6-Amino-2-[(1-methylbutyl)oxy]-9-(tetrahydro-2H-Pyran-4-ylmethyl)-7,9-dihydro-8H-purin-8-one

Participants

Reaction Steps

To a solution of 2-[(1-methylbutyl)oxy]-8-methoxy-9-(tetrahydro-2H-pyran-4-ylmethyl)-9H-purin-6-amine (92 mg) in dry MeOH (9.9 mL) was added 4N HCl in 1,4-dioxane (1.7 mL) and the reaction mixture was stirred at room temperature for 3 h. The reaction was neutralised to pH7 with 2M sodium hydroxide solution and concentrated in vacuo to give an off-white solid. The solid was triturated with water (30 mL) and filtered under reduced pressure to give the title compound as an off-white solid (55 mg).

Provenance & Evidence