Hydrochloric Acid → 6-Amino-2-[(2-cyclopropylethyl)oxy]-9-(tetrahydro-3-furanylmethyl)-7,9-dihydro-8H-purin-8-one

Participants

Reaction Steps

To a solution of 2-[(2-cyclopropylethyl)oxy]-8-methoxy-9-(tetrahydro-3-furanylmethyl)-9H-purin-6-amine (103.8 mg) in methanol (5 mL) was added 4N HCl in 1,4-dioxane (2 mL) and the reaction mixture was stirred at room temperature for 4 h. The reaction was evaporated under reduced pressure to give a gum. Water (3 mL) was added to give a white solid. The mixture was adjusted to pH 7 by adding 2N sodium hydroxide solution and the white solid was filtered off under suction, then washed with a few drops of MeOH. The material was air dried under suction, then in a vacuum oven (50° C.) to give the title compound as white solid (77 mg).

Provenance & Evidence