Hydrochloric Acid → 6-Amino-2-butyloxy-9-[2-(tetrahydro-3-furanyl)ethyl]-7,9-dihydro-8H-Purin-8-one

Participants

Reaction Steps

A solution of 2-butyloxy-8-methoxy-9-[2-(tetrahydro-3-furanyl)ethyl]-9H-purin-6-amine (102 mg) in methanol (1 mL) was treated with 4N HCl in 1,4-dioxane (0.5 mL) for 1.5 h. The reaction was evaporated and the residue treated with water then basified with saturated sodium bicarbonate solution. The resulting solid was filtered, washed with water and dried to give the title compound (65 mg).

Provenance & Evidence