Hydrochloric Acid → HCID 57699825, compound

Participants

Reaction Steps

2-[(Cyclohexylmethyl)oxy]-8-(methoxy)-9-(tetrahydro-2H-pyran-4-ylmethyl)-9H-purin-6-amine (RS105369-181A2) (0.1657 g) was dissolved in methanol (5 mL) and then added 4N hydrogen chloride in 1,4-dioxane (2 mL). The reaction mixture was stirred at room temperature for 4 hours. The reaction mixture was then evaporated under reduced pressure to give a solid that was then suspended in water (1 mL) and methanol (˜2-3 mL) before being neutralised (to pH 7) by the addition of 2N sodium hydroxide. The resultant mixture was evaporated to near dryness before being suspended in water (3 mL) and the solid is filtered off under suction. This solid was then washed with a few drops of methanol and then air-dried under suction before finally being dried to constant weight under vacuo at 50° C. This gave the title compound as a white solid (134 mg).

Provenance & Evidence