Water → 6-Amino-2-{[2-(methoxy)ethyl]oxy}-9-(tetrahydro-3-furanylmethyl)-7,9-dihydro-8H-Purin-8-one
Reaction equation
C[O:2][C:3]1[N:4]([CH2:18][CH:19]2[CH2:23][CH2:22][O:21][CH2:20]2)[C:5]2[C:10]([N:11]=1)=[C:9]([NH2:12])[N:8]=[C:7]([O:13][CH2:14][CH2:15][O:16][CH3:17])[N:6]=2.[H][H].O1CCOCC1.O.[OH-].[Na+]>CO>[NH2:12][C:9]1[N:8]=[C:7]([O:13][CH2:14][CH2:15][O:16][CH3:17])[N:6]=[C:5]2[C:10]=1[NH:11][C:3](=[O:2])[N:4]2[CH2:18][CH:19]1[CH2:23][CH2:22][O:21][CH2:20]1Participants
6
Reactant 4
Product 1
Reagents, catalysts & solvents 1
Procedure
8-(Methoxy)-2-{[2-(methoxy)ethyl]oxy}-9-(tetrahydro-3-furanylmethyl)-9H-purin-6-amine (0.1233 g) was dissolved in methanol (5 mL). To this solution was added 4N hydrogen dioxane (2 mL), stirred at room temperature for 4 hours. The reaction mixture was evaporated under reduced pressure to give a gum. To this material was added water (3 mL) to give a solution, which was then neutralised (to pH 7) using 2N sodium hydroxide. This gave a white solid which was filtered under suction and then washed with a few drops of methanol. The solid was then air-dried under suction before being dried in under vacuo at 50° C. for 2 hours. This gave the title compound as a white solid (86 mg).
Workup
- customThe reaction mixture was evaporated under reduced pressure
- customto give a gum
- customto give a solution, which
- customThis gave a white solid which
- filtrationwas filtered under suction
- washwashed with a few drops of methanol
- customThe solid was then air-dried under suction
- custombefore being dried in under vacuo at 50° C. for 2 hours
Sources & evidence
- ORD record
- ord-36e6a5d0c81f415da30544b0e3701aba
- Source dataset
- uspto-grants-2011_07
- Patent number
- US07977344B2
Reaction notes
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