反应详情

8-(Methoxy)-2-{[2-(methoxy)ethyl]oxy}-9-(tetrahydro-3-furanylmethyl)-9H-purin-6-amine (0.1233 g) was dissolved in methanol (5 mL). To this solution was added 4N hydrogen dioxane (2 mL), stirred at room temperature for 4 hours. The reaction mixture was evaporated under reduced pressure to give a gum. To this material was added water (3 mL) to give a solution, which was then neutralised (to pH 7) using 2N sodium hydroxide. This gave a white solid which was filtered under suction and then washed with a few drops of methanol. The solid was then air-dried under suction before being dried in under vacuo at 50° C. for 2 hours. This gave the title compound as a white solid (86 mg).

1. customThe reaction mixture was evaporated under reduced pressure
2. customto give a gum
3. customto give a solution, which
4. customThis gave a white solid which
5. filtrationwas filtered under suction
6. washwashed with a few drops of methanol
7. customThe solid was then air-dried under suction
8. custombefore being dried in under vacuo at 50° C. for 2 hours