Hydrochloric Acid → HCID 25026757, compound

Participants

Reaction Steps

4M HCl in 1,4-dioxane (3 ml, 12.00 mmol) was added in one portion to a stirred solution of N2-butyl-9-[4-(2,2-dimethyltetrahydro-2H-pyran-4-yl)butyl]-8-(methyloxy)-9H-purine-2,6-diamine (130 mg, 0.321 mmol) in methanol (3 ml) at room temperature and the mixture stirred under nitrogen overnight. The mixture was then concentrated and the residue dissolved in MeOH:DCM (1:15 ml) and loaded onto a 2 g aminopropyl SPE cartridge. The cartridge was washed with MeOH:DCM (1:1, 3 column volumes) and the desired fractions were concentrated in vacuo to give the title compound as a yellow solid (102 mg).

Provenance & Evidence