1,4-Dioxane → 6-Amino-2-{[(1R)-1-methylbutyl]oxy}-9-[2-(tetrahydro-2-furanyl)ethyl]-7,9-dihydro-8H-Purin-8-one

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-{[(1R)-1-methylbutyl]oxy}-8-(methyloxy)-9-[2-(tetrahydro-2-furanyl)ethyl]-9H-purin-6-amine (50 mg, 0.143 mmol) in methanol (10 ml) at room temperature was added 4M HCL in 1,4 dioxane (0.894 ml, 3.58 mmol) to give a pale straw coloured solution. The reaction mixture was stirred at 37° C. for 3 hours, and the solvent removed on a nitrogen blowdown unit overnight. The residue was dissolved in methanol and loaded onto a 2 g aminopropyl SPE cartridge and eluted with methanol. The appropriate fractions were combined and dried under a stream of nitrogen in a blowdown apparatus to give the title compound as a white solid (26 mg).

Provenance & Evidence