Hydrochloric Acid → HCID 57781034, compound

Participants

Reaction Steps

72 mg (0.107 mmol) of the compound of Example 20 are stirred with 2.6 ml of dioxane and 533 μl of LiOH (1M solution in water, 5 eq.) at RT overnight. The mixture is acidified with 1N HCl and diluted with ethyl acetate. It is extracted by shaking twice with water and once with a saturated NaCl solution. The organic phase is dried over magnesium sulfate and freed from the solvent on a rotary evaporator. The residue is dried under HV. 70 mg of the title compound (99% of theory) are obtained.

Provenance & Evidence