Acetonitrile → HCID 86632634, compound

Participants

Reaction Steps

400 mg (0.63 mmol) of 1-[6-fluoro-8-methoxy-3-({[2-methyl-4-(trifluoromethoxy)benzyl]amino}carbonyl)-4-oxo-1-(2,2,2-trifluoroethyl)-1,4-dihydroquinolin-7-yl]piperidine-4-carboxylic acid (Example 47) are suspended in 20 ml of deionized water and 20 ml of acetonitrile at RT. 60.5 μl (66.4 mg, 0.63 mmol) of diethanolamine are added and the mixture is stirred at RT overnight. The resulting solution is freed from the acetonitrile on a rotary evaporator. The aqueous solution which remains was frozen and lyophilized. 475 mg (100% of theory) of residue, which is found by analysis to correspond to the title compound, are obtained

Provenance & Evidence