HuagongsheHuagongshe Chemistry Print Report · For research reference only
cis-3,5-Dimethyl-1-(4-nitrophenyl)piperazine → cis-1,2,6-Trimethyl-4-(4-nitrophenyl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | cis-3,5-Dimethyl-1-(4-nitrophenyl)piperazine | HCID 7059963 | — |
| Reactant | Racemic-1-(2-fluoro-4-nitrophenyl)-trans-2,4,5-trimethylpiperazine | HCID 57664351 | — |
| Product | cis-1,2,6-Trimethyl-4-(4-nitrophenyl)piperazine | HCID 57664389 | 106% |
Reaction Steps
Crude cis-1,2,6-trimethyl-4-(4-nitrophenyl)piperazine (5.55 g, 106% recovery) is prepared according to the method described above for the synthesis of racemic-1-(2-fluoro-4-nitrophenyl)-trans-2,4,5-trimethylpiperazine from cis-3,5-Dimethyl-1-(4-nitrophenyl)piperazine (4.91 g, 20.8 mmol). LCMS-ESI (m/z): calcd for C13H19N3O2, 249; [M+H]+ found, 250.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07977352B2 |
| Source dataset | uspto-grants-2011_07 |
| ORD ID | ord-f313cfa70977415093109683e3c35d45 |
| Source note | uspto-grants-2011_07 |