反应详情

To a 250-mL round bottom flasked is added 10% Pd/C (150 mg). The flask is sealed with a septum, and flushed with a slow stream of N2. racemic-trans-[1,2,5-Trimethyl-4-(4-nitrophenyl)piperazine] (1.28 g, 5.13 mmol) is dissolved in EtOH (30 mL) and transferred via syringe into the flask. The flask is again flushed with N2 and then fitted with a balloon of hydrogen. An outlet needle is inserted through the septum and the flask is flushed with hydrogen before the outlet needle is removed. The resulting slurry is stirred vigorously under the H2 atmosphere at rt. After 24 h the yellow color of the solution dissipates and the hydrogen balloon is removed. The flask is flushed with nitrogen, DCM (24 mL) is added to the reaction mixture, and the resulting slurry is stirred at rt for 24 h. The reaction is filtered through a filtration tube packed with a short column of Celite, the Celite is washed with DCM (2×25 mL), and the combined filtrate evaporated to dryness on a rotary evaporator to provide crude racemic 4-(trans-2,4,5-trimethyl-piperazin-1-yl)-phenylamine (1.11 g, 98% recovery, 97% purity as determined by LC/MS analysis @ UV 254 nm detection). The crude product is used in the next step without further purification. LCMS-ESI (m/z): calcd for C13H21N3, 219; [M+H]+ found, 220.

1. customThe flask is sealed with a septum
2. customflushed with a slow stream of N2
3. customtransferred via syringe into the flask
4. customThe flask is again flushed with N2
5. customfitted with a balloon of hydrogen
6. customAn outlet needle is inserted through the septum
7. customthe flask is flushed with hydrogen before the outlet needle
8. customis removed
9. customthe hydrogen balloon is removed
10. customThe flask is flushed with nitrogen, DCM (24 mL)
11. additionis added to the reaction mixture
12. stirringthe resulting slurry is stirred at rt for 24 h
13. filtrationThe reaction is filtered through a filtration tube
14. washthe Celite is washed with DCM (2×25 mL)
15. customthe combined filtrate evaporated to dryness on a rotary evaporator