反应详情

Using the method described above for the synthesis of 4-(4-isopentylpiperazin-1-yl)aniline, treatment of 1-cyclohexyl-4-(4-nitrophenyl)piperazine (1.0 g, 3.46 mmol) with H2 and 10% Pd/C provided crude 4-(4-cyclohexylpiperazin-1-yl)aniline (0.89 g, 89% recovery, 78% purity as determined by LC/MS analysis @ UV 254 nm detection). The crude product is used in the next step without further purification. LCMS-ESI (m/z): calcd for C16H25N3, 259; [M+H]+ found, 260.