反应详情

To a round bottom flask equipped with a magnetic stir bar was added 2-phenyl-N-{[(4-{[1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]oxy}phenyl)amino]-carbonothioyl}acetamide (0.070 g, 0.14 mmol, 1.0 eq.) and 4M HCl/Dioxane (5 ml). After 5 minutes ether was added. The resulting solid was filtered and washed twice with ether. The solid was further dried under vacuum to give 2-phenyl-N-({[4-(1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)phenyl]amino}carbonothioyl)acetamide (0.057 g, 96% yield). 1H NMR (400 MHz, DMSO): 12.40 (s, 1H), 11.79 (s, 1H), 8.52 (s, 1H), 8.14 (s, 1H), 7.71 (d, 2H), 7.33 (m, 8H), 3.83 (s, 2H); MS (ESI) for C20H16N6O2S: 403 (MH+).

1. customTo a round bottom flask equipped with a magnetic stir bar
2. filtrationThe resulting solid was filtered
3. washwashed twice with ether
4. customThe solid was further dried under vacuum