Hydrochloric Acid → HCID 178520261, compound

Participants

Reaction Steps

To 2-phenyl-N-{[(4-{[9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl]oxy}phenyl)-amino]carbonothioyl}acetamide (190 mg, 0.38 mmol) in 30 mL of dioxane was added 3 mL of 4N HCl in dioxane and let to stir for 1 h. On concentration of the reaction mixture and trituration with ether yielded 2-phenyl-N-({[4-(9H-purin-6-yloxy)phenyl]amino}carbonothioyl)acetamide (102 mg, 65% yield) as a colorless solid. 1H NMR (400 MHz, DMSO d6): δ 12.40 (s, 1H), 11.80 (s, 1H), 8.6 (s, 1H), 8.4 (s, 1H), 7.70 (m, 2H), 7.35 (m, 7H), 3.8 (s, 2H). MS (ESI) for C20H16N6O2S: 433 (MH+).

Provenance & Evidence