1-[2-(2-Hydroxyethoxy)ethyl]piperazine → HCID 58478847, compound

HRID 1011346Notes

Reaction equation

HRID 1011346 reaction equation
[O:1]=[C:2]1[C:10]2[C:5](=[N:6][C:7]([CH:11]=O)=[CH:8][CH:9]=2)[CH2:4][O:3]1.[OH:13][CH2:14][CH2:15][O:16][CH2:17][CH2:18][N:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1>>[OH:13][CH2:14][CH2:15][O:16][CH2:17][CH2:18][N:19]1[CH2:24][CH2:23][N:22]([CH2:11][C:7]2[N:6]=[C:5]3[CH2:4][O:3][C:2](=[O:1])[C:10]3=[CH:9][CH:8]=2)[CH2:21][CH2:20]1

Participants

3

Reactant 2

HCID 1394361-[2-(2-Hydroxyethoxy)ethyl]piperazineHCID 58478784HCID 58478784, compound

Product 1

HCID 58478847HCID 58478847, compoundYield 27.1%

Procedure

In a process similar to that described in Preparation 8, 5-oxo-5,7-dihydro-furo[3,4-b]pyridine-2-carbaldehyde (150 mg, 0.92 mmol) and 1-[2-(2-hydroxyethoxy)ethyl]-piperazine (181 μL, 1.01 mmol) are reacted to provide the title compound as yellow oil (80 mg, 27%).

Workup

  1. customare reacted

Sources & evidence

ORD record
ord-fcd790660cbe40c69ef95f71887b981e
Source dataset
uspto-grants-2011_07
Patent number
US07977351B2

Reaction notes

Loading…