1-[2-(2-Hydroxyethoxy)ethyl]piperazine → HCID 58478812, compound

HRID 1011372Notes

Reaction equation

HRID 1011372 reaction equation
[O:1]=[C:2]1[C:10]2[C:5](=[N:6][C:7]([CH2:11][CH2:12][CH:13]=O)=[CH:8][CH:9]=2)[CH2:4][O:3]1.[OH:15][CH2:16][CH2:17][O:18][CH2:19][CH2:20][N:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1>>[OH:15][CH2:16][CH2:17][O:18][CH2:19][CH2:20][N:21]1[CH2:26][CH2:25][N:24]([CH2:13][CH2:12][CH2:11][C:7]2[N:6]=[C:5]3[CH2:4][O:3][C:2](=[O:1])[C:10]3=[CH:9][CH:8]=2)[CH2:23][CH2:22]1

Participants

3

Reactant 2

HCID 1394361-[2-(2-Hydroxyethoxy)ethyl]piperazineHCID 58478730HCID 58478730, compound

Product 1

HCID 58478812HCID 58478812, compoundYield 79%

Procedure

In a process similar to that described in Preparation 8, 3-(5-Oxo-5,7-dihydro-furo[3,4-b]pyridin-2-yl)-propionaldehyde (76 mg, 0.4 mmol) and 1-[2-(2-hydroxyethoxy)ethyl]-piperazine (66 μL, 0.4 mmol) are reacted to provide the title compound as an oil (110 mg, 79%).

Workup

  1. customare reacted

Sources & evidence

ORD record
ord-89ec576784c941c0bddc61700725add3
Source dataset
uspto-grants-2011_07
Patent number
US07977351B2

Reaction notes

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