3-(Methylamino)propane-1,2-diol → HCID 58478740, compound

HRID 1011379Notes

Reaction equation

HRID 1011379 reaction equation
[O:1]=[C:2]1[C:10]2[C:5](=[N:6][C:7]([CH2:11][CH2:12][CH:13]=O)=[CH:8][CH:9]=2)[CH2:4][O:3]1.[CH3:15][NH:16][CH2:17][CH:18]([OH:21])[CH2:19][OH:20]>>[OH:21][CH:18]([CH2:19][OH:20])[CH2:17][N:16]([CH3:15])[CH2:13][CH2:12][CH2:11][C:7]1[N:6]=[C:5]2[CH2:4][O:3][C:2](=[O:1])[C:10]2=[CH:9][CH:8]=1

Participants

3

Reactant 2

HCID 27341223-(Methylamino)propane-1,2-diolHCID 58478730HCID 58478730, compound

Product 1

HCID 58478740HCID 58478740, compoundYield 52.8%

Procedure

In a process similar to that described in Preparation 8, 3-(5-Oxo-5,7-dihydro-furo[3,4-b]pyridin-2-yl)-propionaldehyde (139 mg, 0.73 mmol) and 3-methylamino-1,2-propanediol (77 mg, 0.73 mmol) are reacted to provide the title compound as an oil (108 mg, 52%).

Workup

  1. customare reacted

Sources & evidence

ORD record
ord-876aef79d4d348d580f17b168291b5b1
Source dataset
uspto-grants-2011_07
Patent number
US07977351B2

Reaction notes

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