HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-2-methyl-1-propanol → 7-Methoxy-3-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)quinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-2-methyl-1-propanol | HCID 11807 | — |
| Reactant | 3-Cyano-7-methoxyquinoline | HCID 15402200 | — |
| Solvent | Chlorobenzene | HCID 7964 | — |
| Product | 7-Methoxy-3-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)quinoline | HCID 23159759 | — |
Reaction Steps
A solution of 7-methoxy-3-cyanoquinoline reported in Tetrahedron Letters 39, 1998, 4013-4016 (1.84 g, 10 mmol) and 2-amino-2-methyl-1-propanol (0.90 g, 10 mmol) in chlorobenzene under nitrogen atmosphere is refluxed for 2 days. The solvent is evaporated under vacuum to afford the desired compound
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07977354B2 |
| Source dataset | uspto-grants-2011_07 |
| ORD ID | ord-18127656e41b453dbea074895ec3edfe |
| Source note | uspto-grants-2011_07 |