HuagongsheHuagongshe Chemistry Print Report · For research reference only
Boron tribromide → 7-Hydroxy-3-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)quinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Boron tribromide | HCID 25134 | — |
| Reactant | 7-Methoxy-3-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)quinoline | HCID 23159759 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 7-Hydroxy-3-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)quinoline | HCID 135618210 | — |
Reaction Steps
A solution of 7-methoxy-3-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)quinoline (2.56 g, 10 mmol) prepared in stage A and BBr3 (7.41 g, 30 mmol) in dichloromethane (40 mL) are stirred for 12 hours at room temperature. The mixture was quenched with saturated sodium hydrogen carbonate. Extraction with dichloromethane, drying (MgSO4) and evaporation furnished the desired compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07977354B2 |
| Source dataset | uspto-grants-2011_07 |
| ORD ID | ord-f08bfad8e287479db8bc5f23ab85c845 |
| Source note | uspto-grants-2011_07 |