HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → 3-Bromo-5-methoxyquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | HCID 23159792 | HCID 23159792 | — |
| Reactant | Sodium Nitrite | HCID 23668193 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-Bromo-5-methoxyquinoline | HCID 23159764 | — |
Reaction Steps
To a solution of 3-(tert-butoxycarbonylamino)-5-methoxyquinoline (2.74 g, 10 mmol) in aqueous 48% HBr (40 mL), NaNO2 (2.1 g, 30 mmol) in water (20 mL) is added at 0° C. The reaction mixture is stirred 1 hour. The reaction mixture is extrated with CH2Cl2 (3×30 mL). After drying over MgSO4, dichloromethane is evaporated affording the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07977354B2 |
| Source dataset | uspto-grants-2011_07 |
| ORD ID | ord-0a7235043210453abccd5a2db4138344 |
| Source note | uspto-grants-2011_07 |