4-Hydroxybenzyl Alcohol → HCID 12963449, compound

Participants

Reaction Steps

To a solution of 5 g (40.3 mmol) of 4-(hydroxymethyl)phenol in 500 mL of acetone was added finely powdered K2CO3 (27.83 g, 0.2 mol) and 3.71 mL (40.3 mmol) of N,N-dimethylcarbamoyl chloride. This mixture was heated under reflux overnight and then filtered. After evaporation of the solvent, a purification by column chromatography on silica gel with cyclohexane/iPrOH (9/1) and as eluent gave 7.16 g (yield: 91%) of compound of molecular formula C10H13NO3. Aspect: white powder.

Provenance & Evidence