Sodium Chloride → 2-Hydroxypropyl-Beta-Cyclodextrin

Participants

Reaction Steps

61 mg (0.21 mmol) of compound described in example 67 and 1.47 g of hydroxypropyl-beta-cyclodextrin (DS 0.58-Mw 1386 g·L−1) were dissolved in 15 mL of dichloromethane and 10 mL of methanol. The limpid mixture was evaporated under reduced pressure at room temperature. The solid obtained was then dissolved in 3 mL of MilliQ water and filtered through filter with 45 micron pore size. The filter was rinsed with 9 mL of MilliQ water. The aqueous solution was then freeze dried giving 2 g of a pale yellow powder containing 4 wt % of product described in example 67 (mol/mol ratio for the complex “dihydro-compound/beta-cyclodextrine”: ⅕). The included molecule is now soluble (20 g·L−1) in a 9 wt % NaCl aqueous solution.

Provenance & Evidence