Lithium Hydroxide → HCID 11965633, compound

Participants

Reaction Steps

A solution of ethyl-3-(3-(neopentylamino)benzo[d]isoxazol-5-yl)benzoate (0.38 g, 1.08 mmol, 1 equiv.) in methanol (4 mL) was cooled to 0° C. and an aqueous solution LiOH*H2O (0.16 g, 2.16 mmol, 2 equiv./in H2O (1.5 mL)) added slowly. The reaction mixture was stirred for 15 h at RT and subsequently concentrated in a vacuum. The residue was absorbed in EtOAc (100 mL), washed with 10% aq. citric acid sol. (2×20 mL), dried (MgSO4) and the solvent removed in a vacuum. The desired product (0.34 g, 97%) is obtained in this manner.

Provenance & Evidence