HCID 59511062, compound → HCID 59511052, compound

HRID 1011469Notes

Reaction equation

HRID 1011469 reaction equation
[C:1]([O:4][CH2:5][CH:6]([N:9]=[N+:10]=[N-:11])[CH2:7][OH:8])(=[O:3])[CH3:2].[C:12]([N:15]1[CH:19]=[CH:18][N:17]=[C:16]1[N+:20]([O-:22])=[O:21])#[C:13][CH3:14]>>[C:1]([O:4][CH2:5][CH:6]([N:9]1[CH:14]=[C:13]([CH2:12][N:15]2[CH:19]=[CH:18][N:17]=[C:16]2[N+:20]([O-:22])=[O:21])[N:11]=[N:10]1)[CH2:7][OH:8])(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 59511062HCID 59511062, compoundHCID 66850847HCID 66850847, compound

Product 1

HCID 59511052HCID 59511052, compoundYield 52%

Conditions

Temperature
60 °C

Procedure

A vial containing Compound 24 (500 mg, 3.14 mmol) and 1-propynyl-2-nitroimidazole (475 mg, 3.14 mmol) was heated at 60° C. overnight. The resultant solid was purified on a silica gel cartridge using EtOAc:Hex as the eluent to afford 504 mg (52% yield) of a white solid.

Workup

  1. customThe resultant solid was purified on a silica gel cartridge

Sources & evidence

ORD record
ord-21769980ed43435ba2281ddd9b26db92
Source dataset
uspto-grants-2011_07
Patent number
US07977361B2

Reaction notes

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