Hydrazine hydrate (1:1) → HCID 178420376, compound

Participants

Reaction Steps

A mixture of cyclopentyl (4-benzyloxy-2-fluorophenyl)methanone (40 g, 0.13 mol) in hydrazine hydrate (50 ml) was refluxed overnight. After cooling to room temperature, the solid was filtered, dissolved in EtOAc, then washed with aqueous NH4Cl and brine. The solution was dried over Na2SO4, filtered and concentrated under vacuum. Purification by flash chromatography (toluene/EtOAc 9/1) gave the expected product (13 g, 45% as solid).

Provenance & Evidence