Sodium Bicarbonate → HCID 178510911, compound

Participants

Reaction Conditions

Reaction Steps

3-cyclohexyl-2-(6-methoxy-1H-indazol-3-yl) propanenitrile (1.61 g, 5.68 mmol) was dissolved in CH2Cl2 and cooled with an ice bath. BBr3/CH2Cl2 1M (8.6 ml, 8.52 mmol) was added to this mixture, which was stirred at 50° C., then poured onto saturated NaHCO3 solution, extracted with ethylacetate, dried over Na2SO4, filtered, concentrated under vacuum and purified by flash chromatography (CH2Cl2/MeOH 98/2). Crystallisation from EtOH gave 780 mg of white crystals (51%). mp 175° C.

Provenance & Evidence