反应详情

The title compound was synthesized from 4-chloro-N-(cis-2-(hydroxymethyl)cyclopentyl)benzenesulfonamide 145 mg, 0.50 mmol), cesium carbonate (326 mg, 1.0 mmol), and 2-(4-(bromomethyl)phenyl)oxazole (143 mg, 0.60 mmol) according to the procedure described for 4-chloro-N-(4-cyanobenzyl)-N-(trans-2-(hydroxymethyl)cyclopentyl)benzenesulfonamide (Example 2) to give 4-chloro-N-(cis-2-(hydroxymethyl)cyclopentyl)-N-(4-(oxazol-2-yl)benzyl)benzenesulfonamide (117 mg, 52%). 1H NMR (400 MHz, CDCl3) δ ppm 7.94 (2H, d, J=8.31 Hz), 7.63-7.69 (3H, m), 7.33-7.44 (4H, m), 7.19 (1H, s), 4.62 (1H, d, J=16.62 Hz), 4.34 (1H, d, J=16.87 Hz), 4.19 (1H, q, J=7.47 Hz), 3.52 (1H, dd, J=11.21, 6.92 Hz), 3.33 (1H, dd, J=11.33, 5.54 Hz), 2.37-2.63 (1H, m), 2.09-2.25 (1H, m), 1.38-1.74 (5H, m), 1.15-1.30 (1H, m). LC/MS R.T.=2.76 min; [M+H]+=447.20. HRMS [M+H]+ calc'd 447.1145, found 447.1137.