Cesium carbonate → 4-chloro-N-(2-fluoro-4-(1,2,4-oxadiazol-3-yl)benzyl)-N-(trans-2-(hydroxymethyl)cyclohexyl)benzenesulfonamide

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Reaction Steps

The title compound was synthesized from 4-chloro-N-(trans-2-(hydroxymethyl)cyclohexyl)benzenesulfonamide (200 mg, 0.66 mmol), cesium carbonate (257 mg, 0.79 mmol), and 3-(4-(bromomethyl)-3-fluorophenyl)-1,2,4-oxadiazole (204 mg, 0.79 mmol) according to the procedure described for N-(4-(1,2,4-oxadiazol-3-yl)benzyl)-4-chloro-N-(trans-2-(hydroxymethyl)cyclohexyl)benzenesulfonamide (Example 11) to give 4-chloro-N-(2-fluoro-4-(1,2,4-oxadiazol-3-yl)benzyl)-N-(trans-2-(hydroxymethyl)cyclohexyl)benzenesulfonamide (75 mg, 24%). 1H NMR (400 MHz, CDCl3) δ ppm 8.77 (s, 1H), 7.91 (dd, J=8.06, 1.51 Hz, 1H), 7.81 (t, J=7.81 Hz, 1H), 7.76 (d, J=10.20 Hz, 1H), 7.74 (d, J=8.60 Hz, 2H), 7.49 (d, J=8.60 Hz, 2H), 4.61 (d, J=15.86 Hz, 1H), 4.40 (d, J=15.61 Hz, 1H), 3.54-3.73 (m, 2H), 3.08 (dd, J=11.96, 1.64 Hz, 1H), 2.64 (br. s., 1H), 1.56-1.78 (m, 3H), 1.49 (ddd, J=12.21, 9.44, 9.32 Hz, 2H), 0.97-1.21 (m, 4H). Analytical HPLC R.T.=23.76 min. MS [M+H]+=480; [M+Na]+=502. HRMS [M+H]+ calcd 480.1160, found 480.1157.

Provenance & Evidence