Cesium carbonate → HCID 59497769, compound

Participants

Reaction Steps

The title compound was synthesized from 5-chloro-N-(trans-2-(hydroxymethyl)cyclohexyl)thiophene-2-sulfonamide (100 mg, 0.32 mmol), cesium carbonate (126 mmol, 0.39 mg), and 2-(4-(bromomethyl)-2,3-difluorophenyl)oxazole (93 mg, 0.39 mmol) according to the procedure described for N-(4-(1,2,4-oxadiazol-3-yl)benzyl)-4-chloro-N-(trans-2-(hydroxymethyl)cyclohexyl)benzenesulfonamide (Example 11) to give 5-chloro-N-(2,3-difluoro-4-(oxazol-2-yl)benzyl)-N-(trans-2-(hydroxymethyl)cyclohexyl)thiophene-2-sulfonamide (28 mg, 17%). 1H NMR (400 MHz, CDCl3) δ ppm 7.78-7.84 (m, 1H), 7.79 (s, 1H), 7.50-7.57 (m, 1H), 7.37 (d, J=4.03 Hz, 1H), 7.32 (s, 1H), 6.95 (d, J=3.78 Hz, 1H), 4.58 (d, J=14.00 Hz, 1H), 4.42 (d, J=14.00 Hz, 1H), 3.53-3.73 (m, 2H), 2.98-3.19 (m, 1H), 2.38 (br. s., 1 H), 1.59-1.84 (m, 3H), 1.40-1.57 (m, 2H), 1.29-1.39 (m, 1H), 1.01-1.26 (m, 3H). Analytical HPLC R.T.=22.41 min. MS [M+H]+=503. HRMS [M+H]+ calc'd 503.0678, found 503.0654.

Provenance & Evidence