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HRID1011524

反应详情

EQUATION

反应方程式

HRID 1011524 的结构方程式

REACTANTS

反应物

4
结构：O=C([O-])[O-].[Cs+].[Cs+]
HCID10796

Cesium carbonate

CCs2O3

结构：O=S(=O)(N[C@@H]1CCCC[C@H]1CO)c1ccc(Cl)cc1
HCID59497770

未命名化合物

结构：O=S(=O)(c1ccc(Cl)cc1)N(Cc1ccc(-c2ncco2)c(F)c1F)[C@@H]1CCCC[C@H]1CO
HCID59497780

未命名化合物

结构：BrCc1ccc(-c2ncon2)cc1
HCID66670019

未命名化合物

PRODUCTS

生成物

1
结构：O=S(=O)(c1ccc(Cl)cc1)N(Cc1ccc(-c2ncon2)cc1)[C@@H]1CCCC[C@H]1CO
HCID59497773

未命名化合物

收率 48.1%

PROCEDURE

实验过程

The title compound was synthesized from 4-chloro-N-((1R,2R)-2-(hydroxymethyl)cyclohexyl)benzenesulfonamide (28 mg, 0.09 mmol), cesium carbonate (36 mg, 0.11 mmol), and 3-(4-(bromomethyl)phenyl)-1,2,4-oxadiazole (26 mg, 0.11 mmol) according to the procedure described for 4-chloro-N-(2,3-difluoro-4-(oxazol-2-yl)benzyl)-N-((1R,2R)-2-(hydroxymethyl)cyclohexyl)benzenesulfonamide (Example 20) to give N-(4-(1,2,4-oxadiazol-3-yl)benzyl)-4-chloro-N-((1R,2R)-2-(hydroxymethyl)cyclohexyl)benzenesulfonamide (20 mg, 48%). MS [M+H]+=462 HRMS [M+H]+ calc'd 462.1254, found 462.1255. Chiral LC: R.T.=16.21 min., 98.0% ee.