反应详情

The title compound was synthesized from N-((1R,2R)-2-(hydroxymethyl)cyclohexyl)-6-(trifluoromethyl)pyridine-3-sulfonamide (50 mg, 0.15 mmol), cesium carbonate (72 mg, 0.22 mmol), and 2-(4-(bromomethyl)-2,3-difluorophenyl)oxazole (50 mg, 0.18 mmol) according to the procedure described for 4-chloro-N-(2,3-difluoro-4-(oxazol-2-yl)benzyl)-N-((1R,2R)-2-(hydroxymethyl)cyclohexyl)benzenesulfonamide (Example 20) to give N-(2,3-difluoro-4-(oxazol-2-yl)benzyl)-N-((1R,2R)-2-(hydroxymethyl)cyclohexyl)-6-(trifluoromethyl)pyridine-3-sulfonamide (41 mg, 52%). 1H NMR (400 MHz, CDCl3) δ ppm 9.07 (d, J=2.01 Hz, 1H), 8.23 (dd, J=8.18, 1.89 Hz, 1H), 7.73-7.84 (m, 3H), 7.44-7.52 (m, 1H), 7.34 (s, 1H), 4.54-4.63 (m, 1H), 4.43-4.53 (m, 1H), 3.77 (td, J=11.58, 3.02 Hz, 1H), 3.60 (dd, J=11.96, 3.15 Hz, 1H), 3.21 (dd, J=11.83, 2.27 Hz, 1H), 3.16 (br. s., 1H), 1.63-1.80 (m, 3H), 1.40-1.61 (m, 2H), 1.35 (dd, J=11.71, 2.14 Hz, 1H), 1.04-1.28 (m, 3H). Analytical HPLC R.T.=22.34 min. HRMS [M+H]+ calc'd 532.1329, found 532.1323.