Cesium carbonate → N-(4-(1,2,4-oxadiazol-3-yl)benzyl)-4-chloro-N-(1-(hydroxymethyl)cyclohexyl)benzenesulfonamide

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Reaction Steps

The title compound was synthesized from 4-chloro-N-(1-(hydroxymethyl)cyclohexyl)benzenesulfonamide (114 mg, 0.38 mmol), cesium carbonate (244 mg, 0.75 mmol), and 3-(4-(bromomethyl)phenyl)-1,2,4-oxadiazole (99 mg, 0.41 mmol) according to the procedure described for N-(4-bromobenzyl)-4-chloro-N-(1-(hydroxymethyl)cyclohexyl)benzenesulfonamide (Example 39) to give N-(4-(1,2,4-oxadiazol-3-yl)benzyl)-4-chloro-N-(1-(hydroxymethyl)cyclohexyl)benzenesulfonamide (16 mg, 9%). 1H NMR (400 MHz, CDCl3) δ ppm 8.75 (1H, s), 8.08 (2H, d, J=8.31 Hz), 7.80 (2H, d, J=8.56 Hz), 7.39-7.45 (4H, m), 4.38 (2H, d, J=5.79 Hz), 4.08-4.12 (2H, m), 1.68-1.82 (2H, m), 1.29-1.49 (8H, m). LC/MS R.T.=2.93 min; [M+Na]+=484.20.

Provenance & Evidence