2,4'-Dibromopropiophenone → 2-Amino-5-(4-bromophenyl)-4-methylpyrrole-3-carboxamide

HRID 1011566노트

반응식

HRID 1011566 반응식
[O-]CC.[Na+].[CH2:5]([C:9]([NH2:11])=[O:10])[C:6]([NH2:8])=[NH:7].Cl.Br[CH:14]([CH3:24])[C:15]([C:17]1[CH:22]=[CH:21][C:20]([Br:23])=[CH:19][CH:18]=1)=O>C(O)C>[NH2:7][C:6]1[NH:8][C:15]([C:17]2[CH:22]=[CH:21][C:20]([Br:23])=[CH:19][CH:18]=2)=[C:14]([CH3:24])[C:5]=1[C:9]([NH2:11])=[O:10]

참가 물질

5

반응물 3

HCID 6039072,4'-DibromopropiophenoneHCID 2723922Sodium ethoxideHCID 3084595Amidinomalonamide hydrochloride

생성물 1

HCID 592859302-Amino-5-(4-bromophenyl)-4-methylpyrrole-3-carboxamide수율 4.1%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Under ice-cooling, sodium ethoxide (1.4 g, 20 mmol) was added to a suspension of malonamamidine hydrochloride (2.8 g, 20 mmol) in dehydrated ethanol (80 mL), and the mixture was stirred for 30 minutes. Moreover, 2,4′-dibromopropiophenone (2.9 g, 10 mmol) was added thereto, and the whole was stirred overnight at room temperature. After the reaction mixture was concentrated in vacuo, the residue was purified by silica gel column chromatography to give the title reference compound (0.12 g) as a white solid (Yield 4%).

후처리

  1. temperatureUnder ice-cooling
  2. stirringthe whole was stirred overnight at room temperature
  3. concentrationAfter the reaction mixture was concentrated in vacuo
  4. customthe residue was purified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-09f4d04e7f19477a81e6e0b5eea19049
출처 데이터셋
uspto-grants-2011_07
특허 번호
US07977371B2

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