Water → HCID 59285839, compound

Participants

Reaction Steps

Boron tribromide in dichloromethane solution (17%, 5.8 mL, 5.8 mmol) was added dropwise to a suspension of 2-aminocarbonylamino-5-(2-methoxyphenyl)pyrrole-3-carboxamide (Compound No. 1-9, 0.40 g, 1.5 mmol) in anhydrous dichloromethane (8 mL) for 7 minutes at −78° C., and the mixture was stirred for 30 minutes. Moreover, the mixture was stirred under ice-cooling for 5 hours, water (25 mL) was added thereto. The precipitated solid was filtered off with chloroform, dried under reduced pressure to give the target compound (0.39 g) quantitatively as a gray solid.

Provenance & Evidence